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Literature summary extracted from

  • Hu, Y.; Wang, J.; Cen, Y.; Zheng, H.; Huang, M.; Lin, X.; Wu, Q.
    ''Top'' or ''bottom'' switches of a cyclohexanone monooxygenase controlling the enantioselectivity of the sandwiched substrate (2019), Chem. Commun. (Camb.), 55, 2198-2201 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.14.13.22 F432I mutation efficiently reverses the inherent enantiopreference of CHMO in the Baeyer-Villiger oxidation of various 4-phenylcyclohexanone derivatives and 4-alkyl-cyclohexanones, producing a series of substituted lactones with inversed configuration Acinetobacter sp.
1.14.13.22 F432Lm mutation efficiently reverses the inherent enantiopreference of CHMO in the Baeyer-Villiger oxidation of various 4-phenylcyclohexanone derivatives and 4-alkyl-cyclohexanones, producing a series of substituted lactones with inversed configuration Acinetobacter sp.
1.14.13.22 L435A mutation efficiently reverses the inherent enantiopreference of CHMO in the Baeyer-Villiger oxidation of various 4-phenylcyclohexanone derivatives and 4-alkyl-cyclohexanones, producing a series of substituted lactones with inversed configuration Acinetobacter sp.
1.14.13.22 L435G mutation efficiently reverses the inherent enantiopreference of CHMO in the Baeyer-Villiger oxidation of various 4-phenylcyclohexanone derivatives and 4-alkyl-cyclohexanones, producing a series of substituted lactones with inversed configuration Acinetobacter sp.

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.22 Acinetobacter sp. P12015
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.22 4-(3-fluorophenyl)cyclohexanone + NADPH + H+ + O2
-
 Acinetobacter sp. 4-(3-fluorophenyl)hexano-6-lactone + NADP+ + H2O
-
 ?
1.14.13.22 4-(3-methylphenyl)cyclohexanone + NADPH + H+ + O2
-
 Acinetobacter sp. 4-(3-methylphenyl)hexano-6-lactone + NADP+ + H2O
-
 ?
1.14.13.22 4-(4-chlorophenyl)cyclohexanone + NADPH + H+ + O2
-
 Acinetobacter sp. 4-(4-chlorophenyl)hexano-6-lactone + NADP+ + H2O
-
 ?
1.14.13.22 4-(4-fluorophenyl)cyclohexanone + NADPH + H+ + O2
-
 Acinetobacter sp. 4-(4-fluorophenyl)hexano-6-lactone + NADP+ + H2O
-
 ?
1.14.13.22 4-(4-methoxyhenyl)cyclohexanone + NADPH + H+ + O2
-
 Acinetobacter sp. 4-(4-methoxyphenyl)hexano-6-lactone + NADP+ + H2O
-
 ?
1.14.13.22 4-(4-methylphenyl)cyclohexanone + NADPH + H+ + O2
-
 Acinetobacter sp. 4-(4-methylphenyl)hexano-6-lactone + NADP+ + H2O
-
 ?
1.14.13.22 4-ethylcyclohexanone + NADPH + H+ + O2
-
 Acinetobacter sp. 4-ethylhexano-6-lactone + NADP+ + H2O
-
 ?
1.14.13.22 4-methylcyclohexanone + NADPH + H+ + O2
-
 Acinetobacter sp. 4-methylhexano-6-lactone + NADP+ + H2O
-
 ?
1.14.13.22 4-pentylcyclohexanone + NADPH + H+ + O2
-
 Acinetobacter sp. 4-pentylhexano-6-lactone + NADP+ + H2O
-
 ?
1.14.13.22 4-phenylcyclohexanone + NADPH + H+ + O2
-
 Acinetobacter sp. 4-phenylhexano-6-lactone + NADP+ + H2O
-
 ?
1.14.13.22 4-propylcyclohexanone + NADPH + H+ + O2
-
 Acinetobacter sp. 4-propylhexano-6-lactone + NADP+ + H2O
-
 ?